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Mayo Collaborative Services v. Prometheus Laboratories

Updated Oct 18, 2026

In brief

The Supreme Court overturned the appeals court and ruled that Prometheus's process was not eligible for a patent.

Where it stands
Decided

Decided 9-0 · March 20, 2012 · Opinion by Justice Breyer

What it’s about
Prometheus held patents on methods for using test results to guide drug doses and sued Mayo over a similar test.
Who it affects
Prometheus's process is not eligible for patent protection under the Court's ruling.

Summary: written with AI from the case record.

Illustration for Mayo Collaborative Services, dba Mayo Medical Laboratories v. Prometheus Laboratories, Inc.
Conceptual illustration · AI-generated

What it's about

The Supreme Court overturned the appeals court and ruled that Prometheus’s process was not eligible for a patent because it relied on a law of nature.

Prometheus held patents on methods that used test results to guide drug doses and sued Mayo over a similar test.

The dispute involved patents on diagnostic methods that use test results to guide drug doses.

Question presented

Can certain types of diagnostic medical tests can be patented?

What the Court decided

Holding

Prometheus’ process is not patent eligible. 628 F. 3d 1347, reversed.

Result
Reversed

The vote

  • Joined the judgment
  • Wrote an opinion
Majority · 9joined the Court's opinion
  1. Breyerwrote the opinion
  2. Kagan
  3. Thomas
  4. Scalia
  5. Kennedy
  6. Ginsburg
  7. Sotomayor
  8. Roberts
  9. Alito
9 justices joined the judgment.

What's next

The appeals court's ruling was overturned; no further action for the parties or a lower court is specified.

Documents

2

Docket activity

10
  • New analysis added

    Oct 18, 2026 · Court records

  • AI analysis generated: Case Briefing

    Oct 18, 2026 · Generated

  • New analysis added

    Oct 18, 2026 · Court records

  • AI analysis generated: Impact Analysis

    Oct 18, 2026 · Generated

  • AI analysis generated: Opinion Summary

    Oct 18, 2026 · Generated

Show 5 more
  • AI analysis generated: Decision Record

    Oct 18, 2026 · Generated

  • Case data updated: summary, question_presented, generation_metadata

    Oct 18, 2026 · Court records

  • Case data updated: question_presented, extraction_metadata

    Oct 17, 2026 · Court records

  • Audio Recording added: Oral Arguments - Mayo Collaborative Services, dba Mayo Medical Laboratories v. Prometheus Laboratories, Inc.

    Oct 30, 2014 · Court records

  • Opinion added: Opinion

    Mar 20, 2012 · Court records

Sources

Primary materials plus reporting. Best-effort analysis: this explainer relies on a mix of primary materials and trusted secondary sources. Official filings and opinions remain authoritative.

Checked Oct 18, 2026Methodology

Court records and filings

Reporting and analysis